Biofuel Research Journal

Biofuel Research Journal

Recent innovations for reviving the ABE fermentation for production of butanol as a drop-in liquid biofuel

Document Type : Review Paper

Author
Hamid Amiri 1, 2
1 Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran.
2 Environmental Research Institute, University of Isfahan, Isfahan 81746-73441, Iran.
10.18331/BRJ2020.7.4.4
Abstract
Butanol is a key microbial product that provides a route from renewable carbohydrate resources to a "drop-in" liquid biofuel, broadening its market in the near future. The acceptable performance of butanol as a neat or a blended fuel in different engines both from the technical and environmental points of view has attracted a wide range of research for reviving the old acetone-butanol-ethanol (ABE) fermentation. In this review, recent findings on fuel characteristics of butanol, different generations of substrate for large scale butanol production, and alternative process designs for upstream, mainstream, and downstream operations have been critically reviewed and discussed. In the upstream, studies devoted to designing and optimization of pretreatments based on prerequisites of butanol production, e.g., maximizing cellulose and hemicellulose recovery and minimizing lignin degradation, are presented. In the mainstream, different microbial systems and process integrations developed for facilitating ABE production (e.g., in-situ butanol removal) are scrutinized. Finally, innovations in ABE recovery and purification as "Achilles Heel" of butanol production processes which directly controls the energy return on investment (EROI), are reviewed and discussed.

Graphical Abstract

Recent innovations for reviving the ABE fermentation for production of butanol as a drop-in liquid biofuel

Highlights

  • Unique properties of butanol as a drop-in liquid biofuel are reviewed.
  • Innovations in ABE production are scrutinized in three categories, upstream, mainstream, and downstream.
  • Recent innovations in pretreatment for waste-based butanol production are reviewed and discussed.
  • Process integrations with significant effects on butanol production are presented.
  • Recent innovations for economically-viable butanol recovery are reviewed and discussed.

Keywords
Biobutanol
ABE fermentation
Clostridia
Lignocellulose
Pretreatment
Waste
[1] Abedini, A., Amiri, H., Karimi, K., 2020. Efficient biobutanol production from potato peel wastes by separate and simultaneous inhibitors removal and pretreatment. Renew. Energy. 160, 269-277.
[2] Alsaker, K.V., Paredes, C., Papoutsakis, E.T., 2010. Metabolite stress and tolerance in the production of biofuels and chemicals: gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum. Biotechnol. Bioeng. 105(6), 1131-1147.
[3] Amiri, H., Karimi, K., Zilouei, H., 2014. Organosolv pretreatment of rice straw for efficient acetone, butanol, and ethanol production. Bioresour. Technol. 152, 450-456.
[4] Amiri, H., Karimi, K., 2015a. Autohydrolysis: A promising pretreatment for the improvement of acetone, butanol, and ethanol production from woody materials. Chem. Eng. Sci. 137, 722-729.
[5] Amiri, H., Karimi, K., 2015b. Improvement of acetone, butanol, and ethanol production from woody biomass using organosolv pretreatment. Bioprocess Biosys. Eng.38(10), 1959-1972.
[6] Amiri, H., Karimi, K., 2016. Integration of autohydrolysis and organosolv delignification for efficient acetone, butanol, and ethanol production and lignin recovery. Ind. Eng. Chem. Res. 55(17), 4836-4845.
[7] Amiri, H., Karimi, K., 2018. Pretreatment and hydrolysis of lignocellulosic wastes for butanol production: Challenges and perspectives. Bioresou. Technol.270, 702-721.
[8] Azimi, H., Tezel, H., Thibault, J., 2019. Optimization of the in situ recovery of butanol from ABE fermentation broth via membrane pervaporation. Chem. Eng. Res. Design 150, 49-64.
[9] Banat, F.A., Al-Shannag, M., 2000. Recovery of dilute acetone–butanol–ethanol (ABE) solvents from aqueous solutions via membrane distillation. Bioprocess Eng. 23(6), 643-649.
[10] Bernton, H., Kovarik, W., Sklar, S., Griffin, B., Woolsey, R., 2010. The forbidden fuel. A History of Power Alcohol. Lincoln/London.
[11] Borden, J.R., Jones, S.W., Indurthi, D., Chen, Y., Terry Papoutsakis, E., 2010. A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing. Metab. Eng. 12(3), 268-281.
[12] Borden, J.R., Papoutsakis, E.T., 2007. Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum. Appl. Env. Microbiol. 73(9), 3061-3068.
[13] Borisov, I.L., Malakhov, A.O., Khotimsky, V.S., Litvinova, E.G., Finkelshtein, E.S., Ushakov, N.V., Volkov, V.V., 2014. Novel PTMSP-based membranes containing elastomeric fillers: Enhanced 1-butanol/water pervaporation selectivity and permeability. J. Membr. Sci. 466, 322-330.
[14] Borisov, I.L., Volkov, V.V., Kirsh, V.A., Roldugin, V.I., 2011. Simulation of the temperature-driven pervaporation of dilute 1-butanol aqueous mixtures through a PTMSP membrane in a cross-flow module. Pet. Chem. 51(7), 542-554.
[15] Cai, D., Zhang, T., Zheng, J., Chang, Z., Wang, Z., Qin, P.Y., Tan, T.W., 2013. Biobutanol from sweet sorghum bagasse hydrolysate by a hybrid pervaporation process. Bioresour. Technol. 145, 97-102.
[16] Cheng, C.L., Che, P.Y., Chen, B.Y., Lee, W.J., Lin, C.Y., Chang, J.S., 2012. Biobutanol production from agricultural waste by an acclimated mixed bacterial microflora. Appl. Energy. 100, 3-9.
[17] Cheng, C., Bao, T., Yang, S.T., 2019. Engineering Clostridium for improved solvent production: recent progress and perspective. Appl. Microbiol. Biotechnol. 103(14), 5549-5566.
[18] Cho, C., Hong, S., Moon, H.G., Jang, Y.S., Kim, D., Lee, S.Y., 2019. Engineering clostridial aldehyde/alcohol dehydrogenase for selective butanol production. Am. Soc. Microbiol. 10(1), e02683-02618.
[19] Cho, C., Lee, S.Y., 2017. Efficient gene knockdown in Clostridium acetobutylicum by synthetic small regulatory RNAs. Biotechnol. Bioeng. 114(2), 374-383.
[20] Doğan, O., 2011. The influence of n-butanol/diesel fuel blends utilization on a small diesel engine performance and emissions. Fuel 90(7), 2467-2472.
[21] BP Energy Outlook. BP, London, UK (2020).
[22] Ezeji, T., Blaschek, H.P., 2008. Fermentation of dried distillers' grains and solubles (DDGS) hydrolysates to solvents and value-added products by solventogenic clostridia. Bioresour. Technol. 99(12), 5232-5242.
[23] Ezeji, T., Qureshi, N., Blaschek, H., 2005. Continuous butanol fermentation and feed starch retrogradation: butanol fermentation sustainability using Clostridium beijerinckii BA101. J. Biotechnol. 115(2), 179-187.
[24] Ezeji, T., Qureshi, N., Blaschek, H.P., 2007. Butanol production from agricultural residues: Impact of degradation products on Clostridium beijerinckii growth and butanol fermentation. Biotechnol. Bioeng. 97(6), 1460-1469.
[25] Farmanbordar, S., Amiri, H., Karimi, K., 2018a. Simultaneous organosolv pretreatment and detoxification of municipal solid waste for efficient biobutanol production. Bioresour. Technol. 270, 236-244.
[26] Farmanbordar, S., Karimi, K., Amiri, H., 2018b. Municipal solid waste as a suitable substrate for butanol production as an advanced biofuel. Energy Convers. Manage. 157, 396-408.
[27] Farmanbordar, S., Amiri, H., Karimi, K., 2020. Synergy of municipal solid waste co-processing with lignocellulosic waste for improved biobutanol production. Waste Manage. 118, 45-54.
[28] Garcia III, A., Iannotti, E.L., Fischer, J.L., 1986. Butanol fermentation liquor production and separation by reverse osmosis. Biotechnol. Bioeng. 28(6), 785-791.
[29] Gauss, W.F., Suzuki, S., Takagi, M., 1976. Manufacture of alcohol from cellulosic materials using plural ferments. 3,990,944, US Patent.
[30] Gottumukkala, L.D., Parameswaran, B., Valappil, S.K., Mathiyazhakan, K., Pandey, A., Sukumaran, R.K., 2013. Biobutanol production from rice straw by a non acetone producing Clostridium sporogenes BE01. Bioresour. Technol. 145, 182-187.
[31] Green, E.M., 2011. Fermentative production of butanol--the industrial perspective. Curr. Opin. Biotechnol. 22(3), 337-343.
[32] Groot, W., Van der Lans, R., Luyben, K.C.A., 1992. Technologies for butanol recovery integrated with fermentations. Process Biochem. 27(2), 61-75.
[33] Gu, X., Huang, Z., Cai, J., Gong, J., Wu, X., Lee, C.-f., 2012. Emission characteristics of a spark-ignition engine fuelled with gasoline-n-butanol blends in combination with EGR. Fuel 93, 611-617.
[34] Guan, W., Shi, S., Tu, M., Lee, Y.Y., 2016. Acetone–butanol–ethanol production from Kraft paper mill sludge by simultaneous saccharification and fermentation. Bioresour. Technol. 200, 713-721.
[35] Harris, L.M., Blank, L., Desai, R.P., Welker, N.E., Papoutsakis, E.T., 2001. Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. J. Ind. Microbiol. Biotechnol. 27(5), 322-328.
[36] Heidari, F., Asadollahi, M.A., Jeihanipour, A., Kheyrandish, M., Rismani-Yazdi, H., Karimi, K., 2016. Biobutanol production using unhydrolyzed waste acorn as a novel substrate. RSC Adv. 6(11), 9254-9260.
[37] Hu, S., Zheng, H., Gu, Y., Zhao, J., Zhang, W., Yang, Y., Wang, S., Zhao, G., Yang, S., Jiang, W., 2011. Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018. BMC Genomics. 12(1), 93.
[38] Huang, W.D., Percival Zhang, Y.H., 2011. Analysis of biofuels production from sugar based on three criteria: Thermodynamics, bioenergetics, and product separation. Energy Env. Sci. 4(3), 784-792.
[39] Jafari, Y., Amiri, H., Karimi, K., 2016. Acetone pretreatment for improvement of acetone, butanol, and ethanol production from sweet sorghum bagasse. Appl. Energy. 168, 216-225.
[40] Jafari, Y., Karimi, K., Amiri, H., 2017. Efficient bioconversion of whole sweet sorghum plant to acetone, butanol, and ethanol improved by acetone delignification. J. Clean. Prod. 166, 1428-1437.
[41] Jang, Y.S., Lee, J., Malaviya, A., Seung, D.Y., Cho, J.H., Lee, S.Y., 2012a. Butanol production from renewable biomass: Rediscovery of metabolic pathways and metabolic engineering. Biotechnol. J. 7(2), 186-198.
[42] Jang, Y.S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., Lee, S.Y., 2012b. Enhanced Butanol Production Obtained by Reinforcing the Direct Butanol-Forming Route in Clostridium acetobutylicum. mBio. 3(5), e00314-00312.
[43] Jang, Y.S., Im, J.A., Choi, S.Y., Lee, J.I., Lee, S.Y., 2014. Metabolic engineering of Clostridium acetobutylicum for butyric acid production with high butyric acid selectivity. Metab. Eng. 23, 165-174.
[44] Jiang, Y., Guo, D., Lu, J., Dürre, P., Dong, W., Yan, W., Zhang, W., Ma, J., Jiang, M., Xin, F., 2018. Consolidated bioprocessing of butanol production from xylan by a thermophilic and butanologenic Thermoanaerobacterium sp. M5. Biotechnol. Biofuels. 11(1), 89.
[45] Jiang Y, Liu J, Jiang W, Yang Y, Yang S., 2015. Current status and prospects of industrial bio-production of n-butanol in China. Biotechnol. Adv. 33(7), 1493-501.
[46] Jiang, Y., Xu, C., Dong, F., Yang, Y., Jiang, W., Yang, S., 2009. Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio. Metabol. Eng. 11(4-5), 284-291.
[47] Joshi, S., Waghmare, J., Sonawane, K., Waghmare, S., 2015. Bio-ethanol and bio-butanol production from orange peel waste. Biofuels. 6(1-2), 55-61.
[48] Juanbaró, J., Puigjaner, L., 1986. Saccharification of concentrated brewing bagasse slurries with dilute sulfuric acid for producing acetone–butanol by Clostridium acetobutylicum. Biotechnol. Bioeng. 28(10), 1544-1554.
[49] Kettering, C.F., 1919. More efficient utilization of fuel. SAE Transactions. 201-219.
[50] Khedkar, M.A., Nimbalkar, P.R., Gaikwad, S.G., Chavan, P.V., Bankar, S.B., 2017. Sustainable biobutanol production from pineapple waste by using Clostridium acetobutylicum B 527: drying kinetics study. Bioresour. Technol. 225, 359-366.
[51] Kudahettige-Nilsson, R.L., Helmerius, J., Nilsson, R.T., Sjöblom, M., Hodge, D.B., Rova, U., 2015. Biobutanol production by Clostridium acetobutylicum using xylose recovered from birch Kraft black liquor. Bioresour. Technol. 176, 71-79.
[52] Kujawska, A., Kujawski, J., Bryjak, M., Kujawski, W., 2015. ABE fermentation products recovery methods—a review. Renew. Sustain. Energy Rev. 48, 648-661.
[53] Kurkijärvi, A., Lehtonen, J., Linnekoski, J., 2014. Novel dual extraction process for acetone–butanol–ethanol fermentation. Sep. Purif. Technol. 124, 18-25.
[54] Kurkijärvi, A.J., Lehtonen, J., 2014. Dual extraction process for the utilization of an acetone–butanol–ethanol mixture in gasoline. Ind. Eng. Chem. Res. 53(31), 12379-12386.
[55] Lee, J.Y., Jang, Y.S., Lee, J., Papoutsakis, E.T., Lee, S.Y., 2009. Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production. Biotechnol. J. 4(10), 1432-1440.
[56] Li, G., Si, Z., Cai, D., Wang, Z., Qin, P., Tan, T., 2020. The in-situ synthesis of a high-flux ZIF-8/polydimethylsiloxane mixed matrix membrane for n-butanol pervaporation. Sep. Purif. Technol. 236, 116263.
[57] Li, S.B., Qian, Y., Liang, Z.W., Guo, Y., Zhao, M.M., Pang, Z.-W., 2016. Enhanced butanol production from cassava with Clostridium acetobutylicum by genome shuffling. World J. Microbiol. Biotechnol. 32(4), 53.
[58] Liao, Y.C., Lu, K.M., Li, S.Y., 2014. Process parameters for operating 1-butanol gas stripping in a fermentor. J. Biosci. Bioeng. 118(5), 558-564.
[59] Lin, X., Wu, J., Fan, J., Qian, W., Zhou, X., Qian, C., Jin, X., Wang, L., Bai, J., Ying, H., 2012. Adsorption of butanol from aqueous solution onto a new type of macroporous adsorption resin: Studies of adsorption isotherms and kinetics simulation. J. Chem. Technol. Biotechnol.  87(7), 924-931.
[60] Liu, W., Ji, S.L., Guo, H.X., Gao, J., Qin, Z.P., 2014. In situ cross-linked-PDMS/BPPO membrane for the recovery of butanol by pervaporation.  J. Appl. Polym. Sci.131(6).
[61] Liu, Z., Ying, Y., Li, F., Ma, C., Xu, P., 2010. Butanol production by Clostridium beijerinckii ATCC 55025 from wheat bran. J. Ind. Microbiol. Biotechnol. 37(5), 495-501.
[62] Long, S., Jones, D.T., Woods, D.R., 1984. Initiation of solvent production, clostridial stage and endospore formation in Clostridium acetobutylicum P262. Appl. Microbiol. Biotechnol. 20(4), 256-261.
[63] Lu, C., Dong, J., Yang, S.T., 2013. Butanol production from wood pulping hydrolysate in an integrated fermentation–gas stripping process. Bioresour. Technol. 143, 467-475.
[64] Lujaji, F., Kristóf, L., Bereczky, A., Mbarawa, M., 2011. Experimental investigation of fuel properties, engine performance, combustion and emissions of blends containing croton oil, butanol, and diesel on a CI engine. Fuel. 90(2), 505-510.
[65] Lütke-Eversloh, T., Bahl, H., 2011. Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production. Curr. Opin. Biotechnol. 22(5), 634-647.
[66] Luyben, W.L., 2012. Pressure-swing distillation for minimum- and maximum-boiling homogeneous azeotropes. Ind. Eng. Chem. Res. 51(33), 10881-10886.
[67] Mann, M.S., Lütke-Eversloh, T., 2013. Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum. Biotechnol. Bioeng. 110(3), 887-897.
[68] Marchal, R., Ropars, M., Pourquie, J., Fayolle, F., Vandecasteele, J., 1992. Large-scale enzymatic hydrolysis of agricultural lignocellulosic biomass. Part 2: Conversion into acetone-butanol. Bioresour. Technol. 42(3), 205-217.
[69] McEnally, C.S., Pfefferle, L.D., 2005. Fuel decomposition and hydrocarbon growth processes for oxygenated hydrocarbons: butyl alcohols. Proc. Combust. Inst. 30(1), 1363-1370.
[70] Mirfakhar, M., Asadollahi, M.A., Amiri, H., Karimi, K., 2017. Phenolic compounds removal from sweet sorghum grain for efficient biobutanol production without nutrient supplementation. Ind. Crops Products 108, 225-231.
[71] Mirfakhar, M., Asadollahi, M.A., Amiri, H. and Karimi, K., 2020. Co-fermentation of hemicellulosic hydrolysates and starch from sweet sorghum by Clostridium acetobutylicum: A synergistic effect for butanol production. Ind. Crops Prod. 151, 112459.
[72] Mishra, R.R., Samantaray, B., Behera, B.C., Pradhan, B.R., Mohapatra, S., 2020. Process optimization for conversion of waste banana peels to biobutanol by a yeast co-culture fermentation system. Renew. Energy. 162, 478-488.
[73] Moradi, F., Amiri, H., Soleimanian-Zad, S., Ehsani, M.R., Karimi, K., 2013. Improvement of acetone, butanol and ethanol production from rice straw by acid and alkaline pretreatments. Fuel. 112, 8-13.
[74] Mosier, N., Wyman, C., Dale, B., Elander, R., Lee, Y.Y., Holtzapple, M., Ladisch, M., 2005. Features of promising technologies for pretreatment of lignocellulosic biomass. Bioresour. Technol. 96(6), 673-686.
[75] National Research Council, 2012. Renewable fuel standard: Potential economic and environmental effects of US biofuel policy. National Academies Press.
[76] Ndaba, B., Chiyanzu, I., Marx, S., 2015. n-Butanol derived from biochemical and chemical routes: A review. Biotechnol. Rep.8, 1-9.
[77] Nguyen, N.-P.-T., Raynaud, C., Meynial-Salles, I., Soucaille, P., 2018. Reviving the Weizmann process for commercial n-butanol production. Nat. Commun. 9(1), 3682.
[78] Oudshoorn, A., van der Wielen, L.A.M., Straathof, A.J.J., 2009. Adsorption equilibria of bio-based butanol solutions using zeolite. Biochem. Eng. J. 48(1), 99-103.
[79] Parekh, S.R., Parekh, R.S., Wayman, M., 1988. Ethanol and butanol production by fermentation of enzymatically saccharified SO2-prehydrolysed lignocellulosics. Enzyme Microbial Technol. 10(11), 660-668.
[80] Patraşcu, I., Bîldea, C.S., Kiss, A.A., 2018. Eco-efficient downstream processing of biobutanol by enhanced process intensification and integration. ACS Sustain. Chem. Eng. 6(4), 5452-5461.
[81] Patraşcu, I., Bîldea, C.S., Kiss, A.A.J.S., 2017. Eco-efficient butanol separation in the ABE fermentation process.  Sep. Puri. Technol. 177, 49-61.
[82] Perret, S., Casalot, L., Fierobe, H.P., Tardif, C., Sabathe, F., Belaich, J.-P., Belaich, A., 2004. Production of heterologous and chimeric scaffoldins by Clostridium acetobutylicum ATCC 824. J. Bacteriol. 186(1), 253-257.
[83] Plaza, A., Merlet, G., Hasanoglu, A., Isaacs, M., Sanchez, J., Romero, J., 2013. Separation of butanol from ABE mixtures by sweep gas pervaporation using a supported gelled ionic liquid membrane: Analysis of transport phenomena and selectivity. J. Membr. Sci. 444, 201-212.
[84] Plaza, P.E., Gallego-Morales, L.J., Peñuela-Vásquez, M., Lucas, S., García-Cubero, M.T., Coca, M., 2017. Biobutanol production from brewer's spent grain hydrolysates by Clostridium beijerinckii. Bioresour. Technol. 244, 166-174.
[85] Potts, T., Du, J., Paul, M., May, P., Beitle, R., Hestekin, J., 2012a. The production of butanol from Jamaica bay macro algae.  Env. Prog. Sustain. Energy 31(1), 29-36.
[86] Potts, T., Du, J., Paul, M., May, P., Beitle, R., Hestekin, J.J.E.P.,  2012b. The production of butanol from Jamaica bay macro algae. Env. Prog. Sustain. Energy 31(1), 29-36.
[87] Qureshi, N., Blaschek, H.P., 2001. Recovery of butanol from fermentation broth by gas stripping. Renew. Energy 22(4), 557-564.
[88] Qureshi, N., Ezeji, T.C., Ebener, J., Dien, B.S., Cotta, M.A., Blaschek, H.P., 2008a. Butanol production by Clostridium beijerinckii. Part I: use of acid and enzyme hydrolyzed corn fiber. Bioresour. Technol. 99(13), 5915-5922.
[89] Qureshi, N., Liu, S., Hughes, S., Palmquist, D., Dien, B., Saha, B., 2016. Cellulosic butanol (abe) biofuel production from sweet sorghum bagasse (ssb): impact of hot water pretreatment and solid loadings on fermentation employing Clostridium beijerinckii P260. BioEnergy Res. 9(4), 1167-1179.
[90] Qureshi, N., Maddox, I.S., 2005. Reduction in butanol inhibition by perstraction: utilization of concentrated lactose/whey permeate by clostridium acetobutylicum to enhance butanol fermentation economics. Food Bioprod. Process. 83(1), 43-52.
[91] Qureshi, N., Saha, B.C., Cotta, M.A., 2007. Butanol production from wheat straw hydrolysate using Clostridium beijerinckii. Bioprocess Biosys. Eng. 30(6), 419-427.
[92] Qureshi, N., Saha, B.C., Dien, B., Hector, R.E., Cotta, M.A., 2010a. Production of butanol (a biofuel) from agricultural residues: Part I–Use of barley straw hydrolysate. Biomass Bioenergy. 34(4), 559-565.
[93] Qureshi, N., Saha, B.C., Hector, R.E., Cotta, M.A., 2008b. Removal of fermentation inhibitors from alkaline peroxide pretreated and enzymatically hydrolyzed wheat straw: Production of butanol from hydrolysate using Clostridium beijerinckii in batch reactors. Biomass Bioenergy. 32(12), 1353-1358.
[94] Qureshi, N., Saha, B.C., Hector, R.E., Dien, B., Hughes, S., Liu, S., Iten, L., Bowman, M.J., Sarath, G., Cotta, M.A., 2010b. Production of butanol (a biofuel) from agricultural residues: Part II–Use of corn stover and switchgrass hydrolysates. Biomass Bioenergy. 34(4), 566-571.
[95] Qureshi, N., Saha, B.C., Hector, R.E., Hughes, S.R., Cotta, M.A., 2008c. Butanol production from wheat straw by simultaneous saccharification and fermentation using Clostridium beijerinckii: Part I—Batch fermentation. Biomass and Bioenergy. 32(2), 168-175.
[96] Qureshi, N., Singh, V., Liu, S., Ezeji, T.C., Saha, B.C., Cotta, M.A., 2014. Process integration for simultaneous saccharification, fermentation, and recovery (SSFR): Production of butanol from corn stover using Clostridium beijerinckii P260. Bioresour. Technol. 154, 222-228.
[97] Ranjan, A., Khanna, S., Moholkar, V., 2013. Feasibility of rice straw as alternate substrate for biobutanol production. Appl. Energy. 103, 32-38.
[98] Ricardo, H.R., 1935. The high-speed internal-combustion engine. Blackie & Son limited.
[99] Rozicka, A., Niemistö, J., Keiski, R.L., Kujawski, W., 2014. Apparent and intrinsic properties of commercial PDMS based membranes in pervaporative removal of acetone, butanol and ethanol from binary aqueous mixtures. J. Membr. Sci. 453, 108-118.
[100] Saisirirat, P., Togbé, C., Chanchaona, S., Foucher, F., Mounaïm-Rousselle, C., Dagaut, P., 2011. Auto-ignition and combustion characteristics in HCCI and JSR using 1-butanol/n-heptane and ethanol/n-heptane blends. Proceed. Combust. Inst. 33(2), 3007-3014.
[101] Sasaki, C., Kushiki, Y., Asada, C., Nakamura, Y., 2014. Acetone–butanol–ethanol production by separate hydrolysis and fermentation (SHF) and simultaneous saccharification and fermentation (SSF) methods using acorns and wood chips of Quercus acutissima as a carbon source. Ind. Crops Prod. 62, 286-292.
[102] Sauer, M., 2016. Industrial production of acetone and butanol by fermentation—100 years later. FEMS Microbiol. Lett. 363(13), fnw134.
[103] Seifollahi, M., Amiri, H., 2020. Enhanced production of cellulosic butanol by simultaneous co-saccharification and fermentation of water-soluble cellulose oligomers obtained by chemical hydrolysis. Fuel. 263, 116759.
[104] Setlhaku, M., Heitmann, S., Górak, A., Wichmann, R., 2013. Investigation of gas stripping and pervaporation for improved feasibility of two-stage butanol production process. Bioresour. Technol. 136, 102-108.
[105] Shah, M., Song, S., Lee, Y., Torget, R., 1991. Effect of pretreatment on simultaneous saccharification and fermentation of hardwood into acetone/butanol. Appl. Biochem. Biotechnol. 28(1), 99-109.
[106] Sharma, P., Chung, W.J., 2011. Synthesis of MEL type zeolite with different kinds of morphology for the recovery of 1-butanol from aqueous solution. Desalination. 275(1), 172-180.
[107] Sun, Z., Liu, S., 2012. Production of n-butanol from concentrated sugar maple hemicellulosic hydrolysate by Clostridia acetobutylicum ATCC824. Biomass Bioenergy. 39, 39-47.
[108] Szwaja, S., Naber, J.D., 2010. Combustion of n-butanol in a spark-ignition IC engine. Fuel. 89(7), 1573-1582.
[109] Tao, L., Tan, E.C.D., McCormick, R., Zhang, M., Aden, A., He, X., Zigler, B.T., 2014. Techno-economic analysis and life-cycle assessment of cellulosic isobutanol and comparison with cellulosic ethanol and n-butanol.  Biofuel Bioprod. Bioref. 8(1), 30-48.
[110] Tao, L., He, X., Tan, E.C., Zhang, M., Aden, A., 2014. Comparative techno‐economic analysis and reviews of n‐butanol production from corn grain and corn stover. Biofuels Bioprod. Bioref. 8(3), 342-361.
[111] Teke, G.M., Pott, R.W.M., 2020. Design and evaluation of a continuous Semi‐Partition Bioreactor (SPB) for in‐situ liquid‐liquid extractive fermentation. Biotechnol. Bioeng. doi.org/10.1002/bit.27550.
[112] Tornatore, C., Marchitto, L., Valentino, G., Corcione, F.E., Merola, S.S., 2012. Optical diagnostics of the combustion process in a PFI SI boosted engine fueled with butanol–gasoline blend. Energy. 45(1), 277-287.
[113] Valles, A., Álvarez-Hornos, F.J., Martínez-Soria, V., Marzal, P., Gabaldón, C., 2020. Comparison of simultaneous saccharification and fermentation and separate hydrolysis and fermentation processes for butanol production from rice straw. Fuel. 282, 118831.
[114] van der Wal, H., Sperber, B.L., Houweling-Tan, B., Bakker, R.R., Brandenburg, W., López-Contreras, A.M.J.B.t., 2013. Production of acetone, butanol, and ethanol from biomass of the green seaweed Ulva lactuca.  Bioresour. Technol. 28, 431-437.
[115] Wang, Y., Ho, S.H., Yen, H.W., Nagarajan, D., Ren, N.Q., Li, S., Hu, Z., Lee, D.J., Kondo, A., Chang, J.S., 2017. Current advances on fermentative biobutanol production using third generation feedstock.  Biotechnol. Adv. 35(8), 1049-1059.
[116] Wang, Y., Zhang, Z.T., Seo, S.O., Choi, K., Lu, T., Jin, Y.S., Blaschek, H.P., 2015. Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system. J Biotechnol. 200, 1-5.
[117] Watts, N., Amann, M., Arnell, N., Ayeb-Karlsson, S., Belesova, K., Boykoff, M., ... , Chambers, J., 2019. The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate. The Lancet. 394(10211), 1836-1878.
[118] Wyman, C.E., 2001. Twenty years of trials, tribulations, and research progress in bioethanol technology. Appl. Biochem. Biotechnol. 91(1), 5-21.
[119] Xiao, H., Gu, Y., Ning, Y., Yang, Y., Mitchell, W.J., Jiang, W., Yang, S., 2011. Confirmation and elimination of xylose metabolism bottlenecks in glucose phosphoenolpyruvate-dependent phosphotransferase system-deficient Clostridium acetobutylicum for simultaneous utilization of glucose, xylose, and arabinose. Appl. Environ. Microbiol. 77(22), 7886-7895.
[120] Xiao, H., Li, Z., Jiang, Y., Yang, Y., Jiang, W., Gu, Y., Yang, S., 2012. Metabolic engineering of D-xylose pathway in Clostridium beijerinckii to optimize solvent production from xylose mother liquid. Metab. Eng. 14(5), 569-578.
[121] Xu, M., Crittenden, J.C., Chen, Y., Thomas, V.M., Noonan, D.S., Desroches, R., Brown, M.A., French, S.P., 2010. Gigaton problems need gigaton solutions. Env. Sci. Technol. 44(11), 4037-4041.
[122] Xu, M., Zhao, J., Yu, L., Tang, I.C., Xue, C., Yang, S.-T., 2015. Engineering Clostridium acetobutylicum with a histidine kinase knockout for enhanced n-butanol tolerance and production. Appl. Microbiol. Biotechnol. 99(2), 1011-1022.
[123] Xue, C., Zhao, J., Liu, F., Lu, C., Yang, S.T., Bai, F.-W., 2013a. Two-stage in situ gas stripping for enhanced butanol fermentation and energy-saving product recovery. Bioresour. Technol. 135, 396-402.
[124] Xue, C., Zhao, X.-Q., Liu, C.G., Chen, L.-J., Bai, F.W., 2013b. Prospective and development of butanol as an advanced biofuel. Biotechnol. Adv. 31(8), 1575-1584.
[125] Xue, C., Zhao, J., Chen, L., Yang, S.T. and Bai, F., 2017. Recent advances and state-of-the-art strategies in strain and process engineering for biobutanol production by Clostridium acetobutylicum. Biotechnology advances, 35(2), 310-322.
[126] Yang, X., Tsai, G.J., Tsao, G.T., 1994. Enhancement of in situ adsorption on the acetone-butanol fermentation by Clostridium acetobutylicum. Sep. Technol. 4(2), 81-92.
[127] Yoo, M., Nguyen, N.P.T., Soucaille, P., 2020. Trends in Systems Biology for the Analysis and Engineering of Clostridium acetobutylicum Metabolism. Trend. Microbiol. 28(2), 118-140.
[128] Yu, H., Chen, Z., Wang, N., Yu, S., Yan, Y., Huo, Y.X., 2019. Engineering transcription factor BmoR for screening butanol overproducers. Metab. Eng. 56, 28-38.
[129] Yu, L., Xu, M., Tang, I.C., Yang, S.T., 2015. Metabolic engineering of Clostridium tyrobutyricum for n-butanol production through co-utilization of glucose and xylose. Biotechnol. Bioeng. 112(10), 2134-2141.
[130] Zhang, J., Wang, M., Gao, M., Fang, X., Yano, S., Qin, S., Xia, R., 2013. Efficient acetone–butanol–ethanol production from corncob with a new pretreatment technology—wet disk milling. BioEnergy Res. 6(1), 35-43.
[131] Zhang, J., Zong, W., Hong, W., Zhang, Z.T., Wang, Y., 2018. Exploiting endogenous CRISPR-Cas system for multiplex genome editing in Clostridium tyrobutyricum and engineer the strain for high-level butanol production. Metab. Eng. 47, 49-59.
[132] Zhang, Y., Boehman, A.L., 2010. Oxidation of 1-butanol and a mixture of n-heptane/1-butanol in a motored engine. Combust. Flame. 157(10), 1816-1824.
[133] Zhang, Y., Han, B., Ezeji, T.C., 2012. Biotransformation of furfural and 5-hydroxymethyl furfural (HMF) by Clostridium acetobutylicum ATCC 824 during butanol fermentation. New Biotechnol. 29(3), 345-351.
[134] Zhu, H., Li, X., Pan, Y., Liu, G., Wu, H., Jiang, M., Jin, W., 2020. Fluorinated PDMS membrane with anti-biofouling property for in-situ biobutanol recovery from fermentation-pervaporation coupled process. J. Membr. Sci. 118225.
Biofuel Research Journal
Volume 7, Issue 4 - Serial Number 4
Autumn 2020
Pages 1256-1266